BDBM380718 6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-6-yl)-1-(oxetan-3-yl)-2-(tetrahydro-2H-pyran-4-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 105

SMILES Cc1cc(cc2n(C)nnc12)N1C(c2c(nc(C3CCOCC3)n2C2COC2)C1=O)c1ccc(Cl)cc1

InChI Key InChIKey=NGGZYQVCSSIVJR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 380718   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM380718(6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d][1,2...)
Affinity DataIC50:  13nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM380718(6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d][1,2...)
Affinity DataIC50:  2.00E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM380718(6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d][1,2...)
Affinity DataIC50:  17nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent