BDBM380786 N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-(4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)acrylamide::US9890168, Compound 4

SMILES C=CC(=O)Nc1cc(Nc2nc(-c3cnc4c(ccn4C)c3)c3cc[nH]c3n2)c(OC)cc1N(C)CCN(C)C

InChI Key InChIKey=BCRGWDZMCMRCPL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380786   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 380786BDBM380786(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 1nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 380786BDBM380786(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 39nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent