BDBM381532 4-Chloro-1-(6-methoxy-pyrimidin- 4-ylmethyl)-3-methyl-1H- pyrazolo[3,4-b]pyridine-5- carboxylic acid (4-trifluoromethyl- phenyl)-amide::US10272074, Example 366

SMILES COc1cc(Cn2nc(C)c3c(Cl)c(cnc23)C(=O)Nc2ccc(cc2)C(F)(F)F)ncn1

InChI Key InChIKey=GGABJPAJUUVOLL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 381532   

TargetGlucocorticoid receptor(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM381532(4-Chloro-1-(6-methoxy-pyrimidin- 4-ylmethyl)-3-met...)
Affinity DataIC50: 50nMAssay Description:The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent