BDBM381954 US20260022114, Compound 546

SMILES C#C[C@H]1C[C@@H]1c1nnc(NC(=O)c2cnc(-n3cc(C)ccc3=O)cc2-c2cc(C(F)F)ncc2OC)s1

InChI Key InChIKey=AJBOFIAPBGSRBO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 381954   

TargetDNA polymerase theta [1-894](Homo sapiens (Human))
Repare Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 381954BDBM381954(US20260022114, Compound 546)
Affinity DataIC50: 0.25nMAssay Description:PolQ ATPase enzyme (1-894) at 0.5 nM is incubated with a 10-point concentration response of inhibitors for 15 min at rt in the following buffer: 50 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent