BDBM383357 4-(9-((5-fluoropyridin-3- yl)oxy)-8,9-dihydro-7H-6- oxa-1,2,2a1- triazabenzo[cd]azulen-4-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10278975, Compound I-91 R::US10278975, Compound I-91 S

SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Cc3cncc(F)c3)c3nnc(c1)n23

InChI Key InChIKey=COZKSRALXOZAFE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 383357   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 383357BDBM383357(US10278975, Compound I-91 R | 4-(9-((5-fluoropyrid...)
Affinity DataIC50: 0.0350nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 383357BDBM383357(US10278975, Compound I-91 R | 4-(9-((5-fluoropyrid...)
Affinity DataIC50: 25.8nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent