BDBM384121 3-(2,3-dichloro- phenyl)-6-(1,7-diaza- spiro[3.5]nonan-7- yl)-1H-pyrazolo[3,4- b]pyrazine::US10280171, Example 7::US10851110, Example 7::US11466017, Example 7

SMILES Clc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCN3)CC2)c1Cl

InChI Key InChIKey=GBRTUCQWCTVZDK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 384121   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384121(US10280171, Example 7 | 3-(2,3-dichloro- phenyl)-6...)
Affinity DataIC50: 79nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
University Of Texas

US Patent
LigandPNGBDBM384121(US10280171, Example 7 | 3-(2,3-dichloro- phenyl)-6...)
Affinity DataIC50: 196nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
University Of Texas

US Patent
LigandPNGBDBM384121(US10280171, Example 7 | 3-(2,3-dichloro- phenyl)-6...)
Affinity DataIC50: 196nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
University Of Texas

US Patent
LigandPNGBDBM384121(US10280171, Example 7 | 3-(2,3-dichloro- phenyl)-6...)
Affinity DataIC50: 196nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent