BDBM384156 (S)-8-(3-(2-chloro-3- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine::US10280171, Example 42

SMILES N[C@@H]1COCC12CCN(c1cnc3c(-c4cccc(F)c4Cl)n[nH]c3n1)CC2

InChI Key InChIKey=FLGHPSVPDMTCRW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 384156   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandChemical structure of BindingDB Monomer ID 384156BDBM384156(US10280171, Example 42 | (S)-8-(3-(2-chloro-3- flu...)
Affinity DataIC50: 63nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent