BDBM384178 US10280171, Example 64B

SMILES NC1[C@@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=RIBDKTGIOVNZBA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384178   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384178(US10280171, Example 64B)
Affinity DataIC50: 70nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384178(US10280171, Example 64B)
Affinity DataIC50: 221nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent