BDBM384193 (R)-N-(1-(1-(6-chloro-5-(3-chloro-2-(4-methoxybenzylamino)isonicotinoyl)-pyrazin-2-yl)-4-methylpiperidin-4-yl)ethyl)-2-methylpropane-2-sulfinamide::US10280171, Example 113a

SMILES COc1ccc(CNc2nccc(C(=O)c3ncc(nc3Cl)N3CCC(C)(CC3)[C@@H](C)NS(=O)C(C)(C)C)c2Cl)cc1

InChI Key InChIKey=BAPWXYXPJRISAE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384193   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384193(US10280171, Example 113a | (R)-N-(1-(1-(6-chloro-5...)
Affinity DataIC50: 100nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384193(US10280171, Example 113a | (R)-N-(1-(1-(6-chloro-5...)
Affinity DataIC50: 180nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent