BDBM384821 2-(dimethylamino)-N-{(1R)-1-[2- fluoro-4-(trifluoromethyl)phenyl]-2,2- dimethylpropyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 37

SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(cc1F)C(F)(F)F)C(C)(C)C

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384821   

TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384821(2-(dimethylamino)-N-{(1R)-1-[2- fluoro-4-(trifluor...)
Affinity DataKi:  0.110nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384821(2-(dimethylamino)-N-{(1R)-1-[2- fluoro-4-(trifluor...)
Affinity DataKi:  0.130nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent