BDBM384882 2-(dimethylamino)-N-[(1R)-1-{3- fluoro-4- [(trifluoromethyl)sulfanyl]phenyl} propyl]-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 98

SMILES CC[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N(C)C)c1ccc(SC(F)(F)F)c(F)c1

InChI Key InChIKey=MFFDIGDILDVHJP-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384882   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384882(2-(dimethylamino)-N-[(1R)-1-{3- fluoro-4- [(triflu...)
Affinity DataKi:  0.230nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384882(2-(dimethylamino)-N-[(1R)-1-{3- fluoro-4- [(triflu...)
Affinity DataKi:  0.540nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent