BDBM385063 (2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 23::US10669245, Example 23::US11117874, Example 23::US11655221, Example 23::US11667615, Example 23::US11680049, Example 23::US20230278969, Example 23

SMILES NC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1

InChI Key InChIKey=GCGGEFOSHQPZEX-PXNSSMCTSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 385063   Sort by

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385063((2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-y...)
Affinity DataIC50:  67.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385063((2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-y...)
Affinity DataIC50:  67.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385063((2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-y...)
Affinity DataIC50:  67.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385063((2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-y...)
Affinity DataIC50:  67.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385063((2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-y...)
Affinity DataIC50:  67.6nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385063((2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-y...)
Affinity DataIC50:  67.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385063((2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-y...)
Affinity DataIC50:  67.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of amino methyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385063((2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-y...)
Affinity DataIC50:  67.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent