BDBM385509 (R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoromethyl)cyclo- propyl)benzoyl)-6-(5-oxa- 2-azaspiro[3.4]octane-2- carbonyl)-4,5,6,7- tetrahydro-1H-indazol-3- yl)-1-methylcyclohex-3- ene-1-carboxylic acid::US10287272, Example 7A::US10287272, Example 8B::US10689369, Example 8B

SMILES CC1(CCC(=CC1)c1nn(C(=O)c2c(Cl)cccc2C2(CC2)C(F)(F)F)c2CC(CCc12)C(=O)N1CC2(C1)CCCO2)C(O)=O

InChI Key InChIKey=IIOLRBSOSSKOMW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 385509   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385509((R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoro...)
Affinity DataIC50: 2nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385509((R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoro...)
Affinity DataIC50: 2nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385509((R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoro...)
Affinity DataIC50: 2nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385509((R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoro...)
Affinity DataIC50: 2nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent