BDBM386810 N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(3,5- difluorophenyl)cyclohexyl)oxy)- methyl)piperidin-3- yl)methanesulfonamide::US10287305, Example 242::US10508083, Example 242::US11292766, Example 242

SMILES CS(=O)(=O)N[C@H]1CCCN([C@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1)C(=O)C1CC1

InChI Key InChIKey=ZUCCGXCBHREFON-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386810   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386810(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(3,...)
Affinity DataEC50:  0.880nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386810(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(3,...)
Affinity DataEC50:  0.880nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386810(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(3,...)
Affinity DataEC50:  0.880nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent