BDBM386863 US10287305, Example 309::US10508083, Example 309::US11292766, Example 309::methyl (2R,3S)-3- ((dimethylsulfamoyl)amino)-2- (((cis-4- phenylcyclohexyl)oxy)methyl)- piperidine-1-carboxylate

SMILES COC(=O)N1CCC[C@H](NS(=O)(=O)N(C)C)[C@@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1

InChI Key InChIKey=INDCLYIGPLPNIG-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386863   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386863(methyl (2R,3S)-3- ((dimethylsulfamoyl)amino)-2- ((...)
Affinity DataEC50:  3.10nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386863(methyl (2R,3S)-3- ((dimethylsulfamoyl)amino)-2- ((...)
Affinity DataEC50:  3.10nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386863(methyl (2R,3S)-3- ((dimethylsulfamoyl)amino)-2- ((...)
Affinity DataEC50:  3.10nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent