BDBM387257 BDBM50551459::US9938274, Comparative Compound C

SMILES OCCOc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1

InChI Key InChIKey=QKVZNUZJUSVSNX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387257   

TargetHepatocyte growth factor receptor(Human)
Nanjing Natinefy Pharmatech

US Patent
LigandPNGBDBM387257(BDBM50551459 | US9938274, Comparative Compound C)
Affinity DataIC50: 5.70nMAssay Description:A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Nanjing Natinefy Pharmatech

US Patent
LigandPNGBDBM387257(BDBM50551459 | US9938274, Comparative Compound C)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of MET (unknown origin) using biotin as substrate preincubated for 5 mins followed by substrate addition and measured after 30 to 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nanjing Natinefy Pharmatech

US Patent
LigandPNGBDBM387257(BDBM50551459 | US9938274, Comparative Compound C)
Affinity DataIC50: 8.5nMAssay Description:A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent