BDBM388758 6-(1-{6-[1-(Tetrahydrofuran-3-yl)-1H-pyrazol-4-yl]imidazo[1,2-a]pyrimidin-3-yl}cyclopropyl)quinoline::US10738052, Example 88::US11261191, Example 88::US9944645, 88

SMILES C1CC1(c1cnc2ncc(cn12)-c1cnn(c1)C1CCOC1)c1ccc2ncccc2c1

InChI Key InChIKey=NSFXUNKEUNPEOM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 388758   

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM388758(US9944645, 88 | 6-(1-{6-[1-(Tetrahydrofuran-3-yl)-...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM388758(US9944645, 88 | 6-(1-{6-[1-(Tetrahydrofuran-3-yl)-...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM388758(US9944645, 88 | 6-(1-{6-[1-(Tetrahydrofuran-3-yl)-...)
Affinity DataIC50: 500nMAssay Description:Briefly, histidine-tagged c-Met catalytic domain fusion protein was used for the assay. IC50 measurements were based on the degree of phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent