BDBM388773 2-Fluoro-N-[1-(methoxymethyl)cyclopropyl]-4-[7-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide::US10738052, Example 103::US11261191, Example 103::US9944645, 103

SMILES COCC1(CC1)NC(=O)c1ccc(cc1F)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1

InChI Key InChIKey=BEEVQDQYKFCBFD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 388773   

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM388773(US9944645, 103 | 2-Fluoro-N-[1-(methoxymethyl)cycl...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM388773(US9944645, 103 | 2-Fluoro-N-[1-(methoxymethyl)cycl...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM388773(US9944645, 103 | 2-Fluoro-N-[1-(methoxymethyl)cycl...)
Affinity DataIC50: 500nMAssay Description:Briefly, histidine-tagged c-Met catalytic domain fusion protein was used for the assay. IC50 measurements were based on the degree of phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent