BDBM388816 N-(Cyclopropylmethyl)-2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide::US10738052, Example 146::US11261191, Example 146::US9944645, 146

SMILES Fc1cc(ccc1C(=O)NCC1CC1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1

InChI Key InChIKey=AKSUMAJHHNCHBG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 388816   

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM388816(US9944645, 146 | N-(Cyclopropylmethyl)-2-fluoro-4-...)
Affinity DataIC50: 500nMAssay Description:Briefly, histidine-tagged c-Met catalytic domain fusion protein was used for the assay. IC50 measurements were based on the degree of phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM388816(US9944645, 146 | N-(Cyclopropylmethyl)-2-fluoro-4-...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM388816(US9944645, 146 | N-(Cyclopropylmethyl)-2-fluoro-4-...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent