BDBM390024 4-amino-1-[(3R)-1-[(E)-4- methoxybut-2-enoyl]-3-piperidyl]-3- (4-phenoxyphenyl)-6H-pyrrolo[2,3- d]pyridazin-7-one::US10323037, Example 37::US9951077, 37

SMILES COC\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12

InChI Key InChIKey=MLWJLQHJELECRT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390024   

TargetTyrosine-protein kinase BTK(Human)
Jiangsu Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 390024BDBM390024(4-amino-1-[(3R)-1-[(E)-4- methoxybut-2-enoyl]-3-pi...)
Affinity DataIC50: 5.01E+4nMAssay Description:The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Jiangsu Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 390024BDBM390024(4-amino-1-[(3R)-1-[(E)-4- methoxybut-2-enoyl]-3-pi...)
Affinity DataIC50: 5.05E+4nMAssay Description:The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
US Patent