BDBM390182 US9951086, Example 71

SMILES CCOc1cc2nn(CC(=O)N3CCOCC3)cc2cc1NC(=O)c1cccc(n1)C(F)(F)F

InChI Key InChIKey=VDZFJGBNFBEPBN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390182   

LigandPNGBDBM390182(US9951086, Example 71)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human IRAK4 expressed in baculovirus infected Hi-5 cells using biotinylated-Ahx-KKARFSRFAGSSPSQASFAEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM390182(US9951086, Example 71)
Affinity DataIC50: 14nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM solution of the test substance in DMSO....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
US Patent