BDBM391321 Cis 2-(4-(3-methoxyazetidin- 1-yl)-1-(4-oxo-3-((4- (trifluoromethoxy)phenyl) amino)-4,5-dihydro-1H- pyrazolo[4,3-c]pyridin-1- yl)cyclohexyl)acetonitrile::US9957264, Example 18-15

SMILES COC1CN(C1)[C@H]1CC[C@](CC#N)(CC1)n1nc(Nc2ccc(OC(F)(F)F)cc2)c2c1cc[nH]c2=O

InChI Key InChIKey=TXPZMRJNTZZIGR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391321   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 391321BDBM391321(US9957264, Example 18-15 | Cis 2-(4-(3-methoxyazet...)
Affinity DataIC50: 151nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 391321BDBM391321(US9957264, Example 18-15 | Cis 2-(4-(3-methoxyazet...)
Affinity DataIC50: 1.14E+3nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent