BDBM391524 US10472358, Example 22::US10781209, Example 22::US11059821, Example 22::US11702416, Example 22::US9957268, Example 22

SMILES COc1cc(-c2cn(C)c(=O)c3[nH]ccc23)c2c(c1)N(C)CC(C(C)C)O2

InChI Key InChIKey=RKMKZCHLXSZZSO-UHFFFAOYSA-N

Data  10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 391524   

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2020
Entry Details
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TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/14/2020
Entry Details
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TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhibitors were...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/17/2025
Entry Details
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TargetBromodomain-containing protein 4 [349-460](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/3/2021
Entry Details
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TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/2/2022
Entry Details
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TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/14/2020
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2020
Entry Details
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TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhibitors were...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/17/2025
Entry Details
Copy BDB DOIUS Patent

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TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/3/2021
Entry Details
Copy BDB DOIUS Patent

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TargetBromodomain-containing protein 4 [42-168](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/2/2022
Entry Details
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TargetBromodomain-containing protein 4 [44-167](Human)
Incyte

US Patent

LigandBDBM391524(US9957268, Example 22 | US10472358, Example 22 | U...)Copy SMILESCopy InChI

Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL