BDBM391540 US9957268, Example 35A

SMILES COc5cc2NC(=O)[C@@H](C1CCCC1)Oc2c(c3cn(C)c(=O)c4[nH]ccc34)c5

InChI Key InChIKey=APVTWFGLNNDNFT-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 391540   

TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent
LigandPNGBDBM391540(US9957268, Example 35A | US12227502, Example 35B)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhibitors were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM391540(US9957268, Example 35A | US12227502, Example 35B)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte

US Patent
LigandPNGBDBM391540(US9957268, Example 35A | US12227502, Example 35B)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent
LigandPNGBDBM391540(US9957268, Example 35A | US12227502, Example 35B)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhibitors were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent
LigandPNGBDBM391540(US9957268, Example 35A | US12227502, Example 35B)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhibitors were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent
LigandPNGBDBM391540(US9957268, Example 35A | US12227502, Example 35B)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhibitors were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent