BDBM392319 6-(4-amino-4-methylpiperidin-1-yl)-3-((2-chloro-4-(2H-tetrazol-5-yl)phenyl)thio)pyrazin-2-amine::US10301278, Example 38

SMILES CC1(N)CCN(c2cnc(Sc3ccc(-c4nn[nH]n4)cc3Cl)c(N)n2)CC1

InChI Key InChIKey=BLWYBYUFZCVGJQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392319   

LigandChemical structure of BindingDB Monomer ID 392319BDBM392319(6-(4-amino-4-methylpiperidin-1-yl)-3-((2-chloro-4-...)
Affinity DataIC50: 23nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent