BDBM393071 US10301317, Example 371::US10301317, Example 84

SMILES Cc1cc(-c2n[nH]c3cc4[nH]c(=O)c([C@H](C)c5ccccc5)cc4cc23)ccn1

InChI Key InChIKey=ZNDOJRRDQPPRCV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393071   

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 393071BDBM393071(US10301317, Example 371 | US10301317, Example 84)
Affinity DataIC50: 50nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 393071BDBM393071(US10301317, Example 371 | US10301317, Example 84)
Affinity DataIC50: 150nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent