BDBM393916 US9969749, Example 1-10::cis or trans-N,N- dimethyl-N'-[6-(1H- pyrazol-4-yl)quinazolin- 4-yl]cyclohexane-1,4- diamine

SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)C(=C\N)\C=N

InChI Key InChIKey=HMJQVEXSCXKUKC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393916   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM393916(US9969749, Example 1-10 | cis or trans-N,N- dimeth...)
Affinity DataIC50: 1nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent