BDBM393951 3-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}quinazolin-6- yl)benzonitrile::US9969749, Example 1-44

SMILES CN(C)[C@H]1CC[C@H](Nc2ncnc3ccc(-c4cccc(C#N)c4)cc23)CC1

InChI Key InChIKey=ABCNFHOEYPVGQJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393951   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 393951BDBM393951(US9969749, Example 1-44 | 3-(4-{[trans-4- (dimethy...)
Affinity DataIC50: 32nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent