BDBM393979 2,3-difluoro-5-{4- [(trans-4-morpholin-4- ylcyclohexyl)amino] quinazolin-6-yl}phenol::US9969749, Example 1-70

SMILES Oc1cc(cc(F)c1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1

InChI Key InChIKey=TWNQNZSDGOYCML-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393979   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM393979(US9969749, Example 1-70 | 2,3-difluoro-5-{4- [(tra...)
Affinity DataIC50: 5nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent