BDBM393989 7-fluoro-N-(trans-4- morpholin-4- ylcyclohexyl)-6-(1H- pyrazol-4-yl)quinazolin- 4-amine::US9969749, Example 1-80

SMILES N\C=C(/C=N)c1cc2c(N[C@H]3CC[C@@H](CC3)N3CCOCC3)ncnc2cc1F

InChI Key InChIKey=GQXRMHCSVCYYOL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393989   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM393989(US9969749, Example 1-80 | 7-fluoro-N-(trans-4- mor...)
Affinity DataIC50: 2nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent