BDBM394043 6-[5-(dimethylamino)-6- fluoropyridin-3-yl]-N- [trans-4-(morpholin-4- yl)cyclohexyl]quinazolin- 4-amine::US9969749, Example 2-31

SMILES CN(C)c1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1

InChI Key InChIKey=SMBVSZRGZUUCKG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 394043   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 394043BDBM394043(US9969749, Example 2-31 | 6-[5-(dimethylamino)-6- ...)
Affinity DataIC50: 73nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent