BDBM394081 6-[6-fluoro-5- (methylamino)pyridin-3- yl]-N-{trans-4-[(2S)-2- methylmorpholin-4- yl]cyclohexyl}quinazolin- 4-amine::US9969749, Example 5-31

SMILES CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCO[C@@H](C)C3)c2c1

InChI Key InChIKey=CILQDKATQFNLIC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 394081   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394081(US9969749, Example 5-31 | 6-[6-fluoro-5- (methylam...)
Affinity DataIC50: 1nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent