BDBM394663 US10308615, Example 19::US10308615, Example 20::[3-(methylsulfonyl)phenyl]{6-[(pyrimidin-5-ylmethyl)amino]pyridin-3-yl}methanone

SMILES CS(=O)(=O)c1cccc(c1)C(=O)c1cnc(NCc2cncnc2)nc1

InChI Key InChIKey=BZSFQWGXVZJHHW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 394663   

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394663(US10308615, Example 19 | [3-(methylsulfonyl)phenyl...)
Affinity DataIC50: 9.40nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394663(US10308615, Example 19 | [3-(methylsulfonyl)phenyl...)
Affinity DataIC50: 17nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394663(US10308615, Example 19 | [3-(methylsulfonyl)phenyl...)
Affinity DataIC50: 28.8nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394663(US10308615, Example 19 | [3-(methylsulfonyl)phenyl...)
Affinity DataIC50: 1.44E+3nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent