BDBM395296 N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide::US10308634, Example 11::US10793545, Example 11::US11897863, Compound Control BAY-1834845::US11992481, Example 11::US12006303, Example 11::US20240132473, Compound BAY-1830839
SMILES CC(C)(O)CCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(cc2n1)C(C)(C)O
InChI Key InChIKey=NWFPCWIBSBZRGV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 395296
Affinity DataIC50: 3.40nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 3.40nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 1(Human)
Zhejiang Hisun Pharmaceutical
Curated by ChEMBL
Zhejiang Hisun Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of IRAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.70nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM solution of the test substance in DMSO....More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.36E+5nMAssay Description:Inhibition of N-terminal His6/GST-tagged recombinant human TrkA (443 to 796 residues) expressed in Sf9 cells using biotinylated-polyGlu,Tyr (4:1) cop...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:The following methods were used to determine the inhibition degree of the preferred compound of the present invention on IRAK4 kinase activity in vit...More data for this Ligand-Target Pair
Affinity DataIC50: 128nMAssay Description:Inhibition of IRAK4 in human THP-1 cells by cell based anti-inflammatory assayMore data for this Ligand-Target Pair