BDBM395618 (R)-1-((7-cyano- 2-(3'-(5-(2-(cis- 3-hydroxycyclo- butylamino)- acetyl)-5,6- dihydro-4H- pyrrolo[3,4-d]- thiazol-2-yl)-2,2'- dimethylbiphenyl- 3-yl)benzo[d]-::US10308644, Example 228::US10800768, Example 229::US11339149, Example 229

SMILES Cc1c(cccc1-c1cccc(-c2nc3CN(Cc3s2)C(=O)CNC2C[C@H](O)C2)c1C)-c1nc2cc(CN3CC[C@](C)(C3)C(O)=O)cc(C#N)c2o1

InChI Key InChIKey=VDUODFJFGSNRSD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 395618   

LigandPNGBDBM395618(US10308644, Example 228 | (R)-1-((7-cyano- 2-(3'-(...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
US Patent

LigandPNGBDBM395618(US10308644, Example 228 | (R)-1-((7-cyano- 2-(3'-(...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 uL. Inhibitors were first serially diluted in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM395618(US10308644, Example 228 | (R)-1-((7-cyano- 2-(3'-(...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
US Patent

LigandPNGBDBM395618(US10308644, Example 228 | (R)-1-((7-cyano- 2-(3'-(...)
Affinity DataIC50: 3.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

LigandPNGBDBM395618(US10308644, Example 228 | (R)-1-((7-cyano- 2-(3'-(...)
Affinity DataIC50: 3.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent