BDBM395664 (2R,5R)-5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2-methyl-1-{[2-(2H-1,2,3- triazol-2- yl)phenyl]carbonyl}piperidine::US10308645, Example 3

SMILES CCc1nc(no1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1

InChI Key InChIKey=GPMBANFZQQENLZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395664   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM395664(US10308645, Example 3 | (2R,5R)-5-(5-ethyl-1,2,4-o...)
Affinity DataIC50: 315nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM395664(US10308645, Example 3 | (2R,5R)-5-(5-ethyl-1,2,4-o...)
Affinity DataIC50: 1.00E+4nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent