BDBM395676 2-{3-[(3R,6R)-6-methyl-1-{[2- (trifluoromethoxy)phenyl]carbonyl}piperidin- 3-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol::US10308645, Example 15

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)(F)F)c1noc(n1)C(C)(C)O

InChI Key InChIKey=NLYNKNHYNZVZME-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395676   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM395676(US10308645, Example 15 | 2-{3-[(3R,6R)-6-methyl-1-...)
Affinity DataIC50: 86nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM395676(US10308645, Example 15 | 2-{3-[(3R,6R)-6-methyl-1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent