BDBM396022 6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(3-chloro-4-methylphenyl)-3-methylpyrimidin-4(3H)-one::US10308660, Example 123

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(N)c(Sc3ccc(Cl)c(C)c3)c(=O)n2C)[C@@H]1N

InChI Key InChIKey=XAWYTSWCGJDSOA-SUMWQHHRSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 396022   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM396022(6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspi...)
Affinity DataIC50:  14nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent