BDBM396454 2-[2-(Azetidin-3-yloxy)-4-chloro-phenoxymethyl]-6-trifluoromethyl-pyridine::US9981909, Example 79

SMILES FC(F)(F)c1cccc(COc2ccc(Cl)cc2OC2CNC2)n1

InChI Key InChIKey=FHNUJMGRUCTXDS-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 396454   

TargetSodium-dependent serotonin transporter(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396454(US9981909, Example 79 | 2-[2-(Azetidin-3-yloxy)-4-...)
Affinity DataKi:  3nMAssay Description:Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396454(US9981909, Example 79 | 2-[2-(Azetidin-3-yloxy)-4-...)
Affinity DataKi:  26nMAssay Description:Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396454(US9981909, Example 79 | 2-[2-(Azetidin-3-yloxy)-4-...)
Affinity DataKi:  69nMAssay Description:Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396454(US9981909, Example 79 | 2-[2-(Azetidin-3-yloxy)-4-...)
Affinity DataKi:  248nMAssay Description:Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396454(US9981909, Example 79 | 2-[2-(Azetidin-3-yloxy)-4-...)
Affinity DataKi:  290nMAssay Description:Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent