BDBM396868 US9981950, Example 75

SMILES Cc1cc(ccc1Cl)-n1cc(Cn2ccnc2CCF)nn1

InChI Key InChIKey=KOJCWZJFTKOHIH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 396868   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM396868(US9981950, Example 75)
Affinity DataIC50: 13.5nMAssay Description:Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM396868(US9981950, Example 75)
Affinity DataIC50: 13.5nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM396868(US9981950, Example 75)
Affinity DataIC50: 13.5nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent