BDBM398136 4-Chloro-1-oxetan-3-yl-1H-indole-3-carboxylic acid (2-cyclopentyl-2-phenyl-ethyl)-amide::US10323000, Compound 70::US10676433, Compound 70

SMILES Clc1cccc2n(cc(C(=O)NCC(C3CCCC3)c3ccccc3)c12)C1COC1

InChI Key InChIKey=PBLLXZFFNURZCS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 398136   

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398136(US10323000, Compound 70 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398136(US10323000, Compound 70 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398136(US10323000, Compound 70 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 300nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398136(US10323000, Compound 70 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 300nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent