BDBM398141 4-Chloro-1-oxetan-3-yl-1H-indole-3-carboxylic acid ((1S,2S,4S)-2-bicyclo[2.2.1]hept-5-en-2-yl-ethyl)-amide::US10323000, Compound 75::US10676433, Compound 75

SMILES O=C(NCC[C@@H]1C[C@@H]2C=C[C@H]1C2)c1cn(C2COC2)c2cccc(Cl)c12

InChI Key InChIKey=FINHVAFWUMJYKD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 398141   

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 398141BDBM398141(US10323000, Compound 75 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 398141BDBM398141(US10323000, Compound 75 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 398141BDBM398141(US10323000, Compound 75 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 398141BDBM398141(US10323000, Compound 75 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent