BDBM399925 3-(4-Cyano-5-fluoro-2-methylphenyl)-N-cyclopropyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide ::US10323042, Example 5::US10738063, Example 5

SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2CCCOc12)C(=O)NC1CC1

InChI Key InChIKey=MJHYQMWSWMXYQH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 399925   

LigandPNGBDBM399925(US10323042, Example 5 | 3-(4-Cyano-5-fluoro-2-meth...)
Affinity DataIC50: 34.1nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

LigandPNGBDBM399925(US10323042, Example 5 | 3-(4-Cyano-5-fluoro-2-meth...)
Affinity DataIC50: 34.1nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

LigandPNGBDBM399925(US10323042, Example 5 | 3-(4-Cyano-5-fluoro-2-meth...)
Affinity DataIC50: 97.4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

LigandPNGBDBM399925(US10323042, Example 5 | 3-(4-Cyano-5-fluoro-2-meth...)
Affinity DataIC50: 97.4nMAssay Description:Human PDE4B1 coding sequence (amino acids 122 to 736 from the sequence with accession number Q07343) with the mutations resulting in the amino acid s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

LigandPNGBDBM399925(US10323042, Example 5 | 3-(4-Cyano-5-fluoro-2-meth...)
Affinity DataIC50: 232nMAssay Description:Human PDE4C1 coding sequence (amino acids 2 to 712 from the sequence with accession number NP_000914.2) was cloned into the baculovirus expression ve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

LigandPNGBDBM399925(US10323042, Example 5 | 3-(4-Cyano-5-fluoro-2-meth...)
Affinity DataIC50: 232nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

LigandPNGBDBM399925(US10323042, Example 5 | 3-(4-Cyano-5-fluoro-2-meth...)
Affinity DataIC50: 1.19E+4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

LigandPNGBDBM399925(US10323042, Example 5 | 3-(4-Cyano-5-fluoro-2-meth...)
Affinity DataIC50: 1.19E+4nMAssay Description:A portion of the human PDE4D3 coding sequence (amino acids 50 to 672 from the sequence with accession number Q08499-2) was cloned into the baculoviru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent