BDBM400100 (1aR,6aR)-5-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)cyclobutyl)amino)-2-oxoacetyl)-N-(2-(difluoromethyl)pyridin-4-yl)-4-methyl-1,1a,6,6a-tetrahydrocyclopropa[b]pyrrolizine-3-carboxamide::US10328053, Compound 78::US10874640, Compound 78::US20230270719, Compound 78

SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccnc(c1)C(F)F

InChI Key InChIKey=FFMFNXBGXAJGTJ-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400100   

TargetCapsid protein(HBV-C)
Gilead Sciences

US Patent
LigandPNGBDBM400100(US10328053, Compound 78 | (1aR,6aR)-5-(2-((3,3-dif...)
Affinity DataEC50:  16.4nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400100(US10328053, Compound 78 | (1aR,6aR)-5-(2-((3,3-dif...)
Affinity DataEC50:  16.4nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400100(US10328053, Compound 78 | (1aR,6aR)-5-(2-((3,3-dif...)
Affinity DataEC50:  16.4nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent