BDBM400114 7-(2-((1-ethynylcyclopropyl)amino)-2-oxoacetyl)-6-methyl-N-(3,4,5-trifluorophenyl)-2,3-dihydro-1H-pyrrolizine-5-carboxamide::US10328053, Compound 92::US10874640, Compound 92::US20230270719, Compound 92

SMILES Cc1c(C(=O)C(=O)NC2(CC2)C#C)c2CCCn2c1C(=O)Nc1cc(F)c(F)c(F)c1

InChI Key InChIKey=LQTRGASOWDJCNG-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400114   

TargetCapsid protein(HBV-C)
Gilead Sciences

US Patent
LigandPNGBDBM400114(US10328053, Compound 92 | 7-(2-((1-ethynylcyclopro...)
Affinity DataEC50:  6.40nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400114(US10328053, Compound 92 | 7-(2-((1-ethynylcyclopro...)
Affinity DataEC50:  6.40nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400114(US10328053, Compound 92 | 7-(2-((1-ethynylcyclopro...)
Affinity DataEC50:  6.40nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent