BDBM400146 N-(3-chloro-4-fluorophenyl)-7-(2-((1-cyano-3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide::US10328053, Compound 130::US10874640, Compound 130::US20230270719, Compound 130

SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C#N)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1

InChI Key InChIKey=BTHWSSNMFYMFFF-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400146   

TargetCapsid protein(HBV-C)
Gilead Sciences

US Patent
LigandPNGBDBM400146(US10328053, Compound 130 | N-(3-chloro-4-fluorophe...)
Affinity DataEC50:  10.4nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400146(US10328053, Compound 130 | N-(3-chloro-4-fluorophe...)
Affinity DataEC50:  10.4nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400146(US10328053, Compound 130 | N-(3-chloro-4-fluorophe...)
Affinity DataEC50:  10.4nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent