BDBM400149 (R)-N-(3,4-difluorophenyl)-6-methyl-7-(2-oxo-2-((1,1,1-trifluoro-3-hydroxy-2-methylpropan-2-yl)amino)acetyl)-2,3-dihydro-1H-pyrrolizine-5-carboxamide::US10328053, Compound 133::US10874640, Compound 133::US20230270719, Compound 133

SMILES Cc1c(C(=O)C(=O)NC(C)(CO)C(F)(F)F)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1

InChI Key InChIKey=DMYUTJPBOWGICR-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400149   

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400149(US10328053, Compound 133 | (R)-N-(3,4-difluorophen...)
Affinity DataEC50:  16.5nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400149(US10328053, Compound 133 | (R)-N-(3,4-difluorophen...)
Affinity DataEC50:  16.5nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargetCapsid protein(HBV-C)
Gilead Sciences

US Patent
LigandPNGBDBM400149(US10328053, Compound 133 | (R)-N-(3,4-difluorophen...)
Affinity DataEC50:  16.5nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent