BDBM400844 2-Amino-N-[4-(1,4-diazepan-1-yl)pyridin-3-yl]thieno[3,2-b]pyridine-3-carboxamide::US10000507, Example 8

SMILES Nc1sc2cccnc2c1C(=O)Nc1cnccc1N1CCCNCC1

InChI Key InChIKey=WSXWGXFJXFZCLM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400844   

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 400844BDBM400844(2-Amino-N-[4-(1,4-diazepan-1-yl)pyridin-3-yl]thien...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 400844BDBM400844(2-Amino-N-[4-(1,4-diazepan-1-yl)pyridin-3-yl]thien...)
Affinity DataIC50: 40nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 400844BDBM400844(2-Amino-N-[4-(1,4-diazepan-1-yl)pyridin-3-yl]thien...)
Affinity DataIC50: 2.00E+3nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent