BDBM401304 US10005756, Compound A75

SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ncc2c1)C(=O)NCc1cc(F)cc(F)c1

InChI Key InChIKey=RNEDPFDUMWDQHL-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 401304   

TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM401304(US10005756, Compound A75)
Affinity DataIC50: 72nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM401304(US10005756, Compound A75)
Affinity DataIC50: 72nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM401304(US10005756, Compound A75)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM401304(US10005756, Compound A75)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM401304(US10005756, Compound A75)
Affinity DataIC50: 92nMAssay Description:The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetMethionine aminopeptidase 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM401304(US10005756, Compound A75)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM401304(US10005756, Compound A75)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed