BDBM401850 2-{2-[(3R,6R)-1-{[2- (Difluoromethoxy)phenyl] carbonyl}-6-methylpiperidin-3- yl]-5-methyl-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 66

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)F)n1nc(C)c(n1)C(C)(C)O

InChI Key InChIKey=UQOXQARHISWGSJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 401850   

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401850(US10010539, 66 | 2-{2-[(3R,6R)-1-{[2- (Difluoromet...)
Affinity DataIC50: 9.60nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401850(US10010539, 66 | 2-{2-[(3R,6R)-1-{[2- (Difluoromet...)
Affinity DataIC50: 3.06E+3nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent